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Tuesday, July 24, 2018

8 a.m. – 4:30 p.m.

Organizer(s): Paul Sharpe (King’s College London, England)
Sponsoring Group/Network: Stem Cell Biology Research

Dental and orofacial tissues are a "treasure chest" of easily accessible stem cell populations that could provide cells for a variety of therapeutic applications. This concept is largely based on the "artificial" in vitro mesencymal stem cell-like properties of many of these cell populations which display multipotent differentiation following appropriate stimulation. However, in vivo, such multipotent differentiation is rarely observed and cell differentiation is highly restricted, often to a single cell type. The emergence of new tools with which to study stem cells in vivo is starting to reveal the true nature of these stem cell populations, their functions, their microenvironments, their heterogeneity, their epigenetic programming, their regulation by signalling pathways and the control of their differentiation. This session will feature interactive presentations highlighting the latest insights on the in vivo analysis of dental and orofacial stem cells and how this impacts upon both the potential therapeutic applications of these cells and the development of new clinical approaches to manipulate cell in vivo.

Learning Objectives:

  1. To understand why the behavior and properties of dental and orofacial mesenchymal stem cells in vitro does not reflect their properties and functions in vivo and why this is important for the development of stem cell-based therapeutic approaches.
  2. To understand the significance of dental and orofacial stem cell heterogeneity, the impact of the local environment and the interrelationships between different cell populations that constitute a stem cell "niche".
  3. To learn about the very latest developments in understanding how stem cells are mobilized to elicit tissue repair following injury and how this can be used to develop new clinical approaches in dentistry.


Understanding Stem Cell Microenvironments
Paul Sharpe, King’s College London, England

Periodontal Ligament Stem Cells
Yang Chai, University of Southern California, Los Angeles, USA

Wnt Signalling in Regeneration and Repair
Jill Helms, Stanford University, California, USA

Dental Stem Cell Exosomes
Rachel Waddington, Cardiff University, Wales

Controlling Stem Cell Differentiation with Mechanical Forces
Eileen Gentleman, King’s College London, England

Stem Cell Applications of Nanoneedle Technology
Ciro Chiappini, King’s College London, England

Commercialization of Cell Products
Paul Kemp, HairClone Inc., Manchester, England

Mechanisms of Immune Modulation by Mesenchymal Stem Cells
Francesco Dazzi, King’s College London, England

The Power of Single Cell RNA Sequencing in Dental Research
Igor Adameyko, Karolinska Institute, Solina, Sweden

Hair Regeneration and Rejuvenation – Lessons for Teeth?
Claire Higgins, Imperial College London, England