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Indu S. Ambudkar - November 2015

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Indu S. Ambudkar, Ph.D., is chief, Molecular Physiology and Therapeutics Branch and Secretory Physiology Section at the National Institute of Dental and Craniofacial Research. She earned her B.Sc. and M.Sc. from Isabella Thoburn College, Lucknow, India; and her Ph.D. from Madurai Kamaraj University, Madurai, India.  

Ambudkar has significantly contributed toward establishing the role of Ca2+ in the salivary secretory process as well as dysfunctions due to radiation and immune disorders. Her studies suggest a link between reduced levels of key Ca2+ signaling proteins and the development of Sjogren’s Syndrome. Her studies demonstrate that in salivary glands the channel protein Transient Receptor Potential Melastatin-like 2, a Ca2+-permeable non selective cation channel, contributes to loss of salivary gland function during radiation and oxidative stress. Consequently, reducing the function of this cation channel, could protect the glands from the deleterious effects of radiation.