AADR Oral Health Effects of Tobacco Products:
Science and Regulatory Policy

 

Friday, September 14, 2018
Hyatt Regency Bethesda, Md.

 

Funding for this conference is made possible, in part, by the Food and Drug Administration through grant (1R13FD006142). Views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government. 

Book your hotel stay at the Hyatt Regeny Bethesda by August 13, 2018 to take advantage of a discounted rate for attendees.

Time

Activity

Introduction
Session Chair: Christopher H. Fox, Executive Director, American Association for Dental Research

8:30 a.m.

Welcome and Opening Remarks
Raul I. Garcia, Boston University School of Dental Medicine

 

Session I: Perspectives on Tobacco Regulatory Policy
Session Chair: Elizabeth Kaye, Boston University School of Dental, Mass. 

 

 Objective: This session will be used to educate the audience about FDA tobacco regulatory policy and how science is used during the regulatory process. 

8:45 a.m.

Mitch Zeller, Food and Drug Administration Center for Tobacco Products, Silver Spring, Md.
Topic: Tobacco regulatory science and policy from the perspective of the FDA, research gaps, and the role of the scientific community

9:05 a.m.

Greg Connolly, Northeastern University Bouvé College of Health Sciences and School of Law, Boston, Mass.
Topic: Regulatory science of tobacco products and oral health from the perspective of a public health researcher and the shift from systemic to local exposures in the tobacco harm reduction paradigm

 9:25 a.m.

Discussion

Session II: Combusted Tobacco (Inhaled and non-inhaled) Products
Session Chair: Raul I. Garcia, Boston University School of Dental, Mass.

Objective: Speakers will give presentations on the oral health effects of smoked or combustible tobacco products regulated by the FDA, including hookah, cigarettes/roll-your-own tobacco, cigars and pipe tobacco.

9:40 a.m.

Stephen Hecht, University of Minnesota Medical School, Minneapolis
Topic: Chemical carcinogenesis of combustible tobacco product ingredients with a focus on DNA-damaging agents

10:00 a.m.

Ilona Jaspers, University of North Carolina-Chapel Hill School of Medicine
Topic: Effect of combustible tobacco products on mucosal immunity

10:20 a.m.

Discussion

10:35 a.m.

Break

Session III: Non-combusted Tobacco (Smokeless Tobacco)
Session Chair: Purnima Kumar, The Ohio State University College of Dentistry, Columbus

Objective: Speakers will give presentations on the oral health effects of non-smoked or non-combustible tobacco products regulated by the FDA, including dissolvable tobacco, snuff, snus and chewing tobacco. Speakers will be asked to evaluate claims of modified or reduced risk where applicable with respect to the oral cavity.

10:45 a.m.

Scott L. Tomar, University of Florida College of Dentistry, Gainesville
Topic: Oral diseases associated with smokeless tobacco products, trends in market share of flavored noncombustibles and regulations on flavorings in these products

11:05 a.m.

Richard L. Gregory, Indiana University School of Dentistry, Indianapolis
Topic: Effect of smokeless tobacco product ingredients on the oral microbiome

11:25 a.m.

Irina Stepanov, University of Minnesota School of Public Health, Minneapolis
Topic: Carcinogenesis of smokeless tobacco product ingredients and evaluation of reduced risk claims of smokeless tobacco products

11:45 p.m.

Discussion

12:00 p.m.

Lunch*

Session IV: Novel Nicotine Delivery Systems
Session Chair: Scott Tomar, University of Florida College of Dentistry, Gainesville

Objective: Speakers will give presentations on the oral health effects of electronic nicotine delivery systems (ENDS). Speakers will be asked to evaluate claims of modified or reduced risk where applicable with respect to the oral cavity. Because ENDS are relatively new products, identifying research and regulatory gaps will be especially important in this session.

1:00 p.m.

Pamela Clark, University of Maryland School of Public Health, College Park
Topic: User preferences and use patterns and factor that may influence attractiveness of novel nicotine delivery systems and impact on oral health

1:20 p.m.

Purnima Kumar, The Ohio State University College of Dentistry, Columbus
Topic: Evaluating the effect of e-cigarettes on the oral microbiome using OMICS research methods

1:40 p.m.

Deepak Saxena, New York University College of Dentistry, New York
Topic: Effects of e-cigarette aerosol on epithelial cells, oral microbiome and novel research questions on effects of e-cigarettes on the oral cavity

2:00 p.m.

Discussion

Session V: In Vitro Models, Standards and Experimental Methods
Session Chair: Deepak Saxena, New York University College of Dentistry, New York

Objective: Speakers will give presentation about appropriate models and experimental methods for testing toxicity of tobacco products on the oral cavity. This will be especially important for accurate testing of new tobacco products. This session is also timely given the FDA’s current review of using higher order mammals in tobacco research.  This session will address the merits of various testing methods and models.

2:15 p.m.

Jeffrey Kim, American Dental Association Foundation Volpe Research Center, Gaithersburg, Md.
Topic: E-cigarette testing devices and reference materials

2:35 p.m.

Michael Bachelor, MatTek Corporation, Ashland, Mass.
Topic: 3D tissue-based assays to test oral health effects of tobacco products

2:55 p.m.

Terry Gordon, New York University School of Medicine, New York
Topic: What oral health researchers can learn from animal models of pulmonary effects of tobacco products

3:15 p.m.

Tara Aghaloo, University of California, Los Angeles School of Dentistry
Topic: Development of animal models of oral health effects of tobacco products

3:35 p.m.

Discussion

3:50 p.m.

Break

 

Conference Summary and Next Steps
Session Chair: Christopher H. Fox, Executive Director, American Association for Dental Research, Alexandria, Va.

4:00 p.m.

Judith S. Gordon, University of Arizona College of Nursing, Tucson
Topic: Role of dentists in tobacco use cessation

4:20 p.m. Overall Discussion
4:50 p.m.

Raul I. Garcia, Boston University School of Dental, Mass.
Topic: Next Steps

5:30 p.m.

Adjourn

5:30 p.m.

Reception*

*No FDA funds will be used towards food or beverages for the conference.


Funding for this conference is made possible, in part, by the Food and Drug Administration through grant (1R13FD006142). Views expressed in written materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organization imply endorsement by the United States Government.