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IADR/AADR Announce Winners of the William J. Gies Awards

Alexandria, Va., USA – The International and American Associations for Dental Research (IADR/AADR) have announced the 2016 recipients of the IADR/AADR William J. Gies Award for Biological Research. The award for Biological Research will be presented at the 45th Annual Meeting & Exhibition of the AADR in Los Angeles, Calif., USA, on March 16. The Biomaterials & Bioengineering Research and Clinical Research categories will be presented at the IADR General Session & Exhibition in Seoul, Republic of Korea on June 22, 2016.

These awards, for the best papers published in the IADR/AADR Journal of Dental Research, are presented in three categories: Biological, Biomaterials & Bioengineering and Clinical. The award is named for William J. Gies, the founder of the Journal of Dental Research. Nominations may be made by any person, and the papers to be chosen must describe work which has very significantly advanced knowledge in some aspect of dental research. Papers eligible for consideration are those published during the 12-month period (July-June) immediately preceding the AADR Annual Meeting and IADR General Session. The award consists of a monetary award of $1,000 and a plaque. The Gies Award is open to anyone who publishes in the Journal of Dental Research, the official publication of the IADR/AADR.

The award in the Biological Research category is being presented to Thomas E. Van Dyke, Hatice Hasturk, Alpdogan Kantarci, Marcelo Freire, Daniel Nguyen, Jesmond Dalli and Charles N. Sherhan for the paper “Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis,” J Dent Res 94: 148-156. Therapies to reverse tissue damage from osteolytic inflammatory diseases are limited by the inability of current tissue-engineering procedures to restore lost hard and soft tissues. There is a critical need for new therapeutics in regeneration. In addition to scaffolds, cells, and soluble mediators necessary for tissue engineering, control of endogenous inflammation is an absolute requirement for success.

Although significant progress has been made in understanding natural resolution of inflammation pathways to limit uncontrolled inflammation in disease, harnessing the biomimetic properties of proresolving lipid mediators has not been demonstrated. The authors of this study reported the use of nano-proresolving medicines (NPRM) containing a novel lipoxin analog (benzo-lipoxin A4, bLXA4) to promote regeneration of hard and soft tissues irreversibly lost to periodontitis in an animal model. In this proof-of-principle experiment, NPRM-bLXA4 dramatically reduced inflammatory cell infiltrate into chronic periodontal disease sites treated surgically and dramatically increased new bone formation and regeneration of the periodontal organ. These findings indicate that NPRM-bLXA4 is a mimetic of endogenous resolving mechanisms with potent bioactions that offers a new therapeutic tissue-engineering approach for the treatment of chronic osteolytic inflammatory diseases.

About the Journal of Dental Research
The IADR/AADR Journal of Dental Research is a multidisciplinary journal dedicated to the dissemination of new knowledge in all sciences relevant to dentistry and the oral cavity and associated structures in health and disease. At .02261, the JDR holds the highest Eigenfactor Score of all dental journals publishing original research and continues to be ranked number one in Article Influence Score, reflecting the influential nature of the Journal’s content.

About the International Association for Dental Research
The International Association for Dental Research (IADR) is a nonprofit organization with nearly 12,000 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge to improve oral health, (2) supporting the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit www.iadr.org. The American Association for Dental Research (AADR) is the largest Division of IADR, with more than 3,700 members in the United States. To learn more, visit www.aadr.org.

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