Systematic Review Finds SDF Efficacious for Caries Prevention
Alexandria, VA, USA – At the 95th General Session & Exhibition of the International Association for Dental Research (IADR), researcher Branca Oliveira presented an abstract titled “SDF for Caries Prevention in Primary Teeth: A Systematic Review.” The IADR General Session was held in conjunction with the 46th Annual Meeting of the American Association for Dental Research and the 41st Annual Meeting of the Canadian Association for Dental Research.
The researchers reviewed nine electronic databases, four registers of ongoing trials and the reference lists of identified review articles to examine if silver diammine fluoride (SDF) application results in caries prevesnion.The search yielded 2,155 unique records. Examining titles and abstracts for randomized or quasi-randomized trials addressing SDF for caries prevention in primary teeth, with 12 months of follow-up or more, identified 49 publications. Full-texts were independently read by two reviewers. The same reviewers independently extracted data and assessed for potential bias trials that met the inclusion criteria. A third reviewer resolved disagreements. Differences in caries increment (decayed, missing and filled surfaces or teeth - dmfs or dmft) between SDF and no treatment, placebo or active treatment groups were pooled as weighted mean difference (WMD) using fixed effect meta-analyses in Stata 14 when data from more than one study was available.
As a result, four trials met the inclusion criteria. Two trials compared SDF to placebo, one compared SDF to both placebo and sodium fluoride varnish (FV) and one compared SDF to high viscosity glass-ionomer cement (GIC). All studies had at least one domain with unclear or high risk of bias. At 12 months of follow-up, GIC was more effective than SDF but the difference between them was not statistically significant (WMD, dmft: 0.19; 95% CI -1.14 to 1.52). At 24 months of follow-up SDF was more effective than placebo (WMD, dmfs: -1.16; 95% CI -1.48 to -0.83) and FV (WMD, dmfs: -0.43; 95% CI -0.70 to -0.16). The authors concluded that SDF is an efficacious agent for caries prevention when compared to placebo or fluoride varnish.
This is a summary of abstract #3446 titled “SDF for Caries Prevention in Primary Teeth: A Systematic Review” that was presented by Branca Oliveira on Saturday, March 25, 2017, 11 a.m. – 12:15 a.m. at Moscone West, San Francisco, Calif. USA.
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The International Association for Dental Research (IADR) is a nonprofit organization with nearly 11,000 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit www.iadr.org.