Guidelines for Fluoride Intake — Are They Appropriate?
Alexandria, Va., USA – The appropriate use of fluoride has transformed oral health over the past 70 years, in part due to the guidelines created for fluoride intake. Recently, researchers are questioning these longstanding guidelines which served as advisory recommendations for decades. This issue of Advances in Dental Research, an e-Supplement to the Journal of Dental Research (JDR), presents the proceedings of a symposium at the 95th General Session of IADR in San Francisco, USA and includes reviews that critically examine the current guidelines for fluoride intake.
Since the benefits of fluoride in drinking water were first recognized, it has been accepted that fluoride is ingested and that remains the basis for automatic delivery. However, sources of ingested fluoride have changed and in parallel the prevalence and severity of dental caries and dental fluorosis have changed, leading to the idea that it is time to re-visit guidance on fluoride intake. Optimum fluoride intake should balance the prevention of dental caries with minimizing the occurrence of undesirable dental fluorosis.
“Guidelines for fluoride intake were first proposed when water was the only important source of fluoride. Now, there is a variety of ways of delivering fluoride and it was time to review these guidelines, considering current knowledge of the balance of benefit and risk,” said guest editor Andrew Rugg-Gunn, Newcastle University, UK and the Borrow Foundation. “Experts from around the world gave reassurance that the current optimum range of fluoride intake is soundly based and that there is good evidence for raising the upper limit of fluoride intake. With the increase in the use of fluoride for preventing caries in adults, different guidance should be given for fluoride intake in adults compared with infants and young children.”
“While changes to current guidance on adequate intake and upper limit of fluoride intake have not been settled, it was agreed that there are strong grounds for reconsidering current guidelines,” said IADR President Angus William G. Walls, University of Edinburgh, who also contributed to this issue. “Further research and international discussion is needed to answer the question posed by the title of this symposium.”
Importantly, the symposium prioritized the following research gaps:
What level of dental fluorosis is acceptable to populations globally given the benefit of caries reduction?
What is the best method for measuring total fluoride intake and exposure?
What is the best way to estimate total fluoride intake in children from birth to 3 to 4 y of age exposed to fluoridated or nonfluoridated water or fluoridated salt?
What is the best method to evaluate the patterns of fluid intake of children across different zones with different outdoor air temperatures?
Do we need periodical analyses of fluoride concentrations in infant formula, bottled water, and infant foods?
Do we need to validate biomarkers of exposure to fluoride?
What is the effect of different types of exercise on the metabolism of fluoride?
What is the relationship between gene polymorphisms and enamel fluorosis?
What is the relationship between malnutrition and enamel fluorosis?
Is supplementation with calcium helpful to reduce enamel fluorosis?
What are the pre-eruptive effects of fluoride on caries progression into dentin?
What is the efficacy of low-fluoride toothpastes whose formulations have been modified to increase the anticaries efficacy?
These reviews, as well as summary of the discussion during the symposium, are included in this issue of Advances in Dental Research, an e-supplement to the Journal of Dental Research.
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About Advances in Dental Research
Advances in Dental Research is an e-supplement supplement to the Journal of Dental Research (JDR). A subscription to JDR grants you access to the articles in Advances in Dental Research. This journal is a member of the Committee on Publication Ethics (COPE).
About the Journal of Dental Research
The IADR/AADR Journal of Dental Research (JDR) is a multidisciplinary journal dedicated to the dissemination of new knowledge in all sciences relevant to dentistry and the oral cavity and associated structures in health and disease. At 0.02225, the JDR holds the highest Eigenfactor® Score of all dental journals publishing original research. The JDR ranks #1in Article Influence and #2 in the Two-Year Journal Impact Factor rankings with a rating of 4.755 according to the 2016 Journal Citation Reports® (Clarivate Analytics, 2017).
About the International Association for Dental Research
The International Association for Dental Research (IADR) is a nonprofit organization with over 10,000 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit www.iadr.org. The American Association for Dental Research (AADR) is the largest Division of IADR, with more than 3,500 members in the United States. To learn more, visit www.aadr.org.