Structure and function relationships at different length scales are frequently discussed in varied fields of science and engineering, since unique properties may only be understood at one or another of these length scales.  These relationships are built using robust interfaces that permit correlating datasets from multiple microscopies and spectroscopies, including X-ray, electron and light imaging modalities. These relationships unfold the functional relevance of biological processes at multiple scales [from millimeter (10-3 m) to nanometers (10-9 m)] while gathering contextual information. While light microscopy, through immunolabelling and fluorescence, can provide localization of two or three proteins in a single image, electron microscopy can reveal exquisite detail of all cellular contents at a nanometer level as well as target proteins to which labels are attached. This allows extracting function within the context of larger landscapes of tissues. Imaging and thereby visualization of this foundation of structural biology will be detailed through various presentations within this symposium on bioimaging that will highlight correlative microscopy and spectroscopy to provide key insights into biofunction.    

In addition, in the afternoon session attendees will be able to choose further imaging discussions or a discussion on mentoring and faculty development.

More Information: 

Speaker Bios 



8 a.m. – 8:10 a.m.          Welcome   Jack Ferracane, Grayson Marshall, Sunita Ho, Sally Marshall
Jack Ferracane welcomes participants on behalf of IADR/AADR Grayson Marshall welcomes them to San Francisco and introduces the other UCSF team members who will coordinate and organize the sessions.

Correlative Imaging – Sunita Ho (UCSF, professor of biomaterials and bioengineering), chair

8:10 a.m. – 8:20 a.m.      Sunita Ho – Imaging in Focus 

8:25 a.m. – 9:15 a.m.      Tom Lang (UCSF, professor of radiology) – Predicting Structural Failure of Bone and Medical Images

9:15 a.m. – 10:35 a.m.    Sunita Ho (UCSF, professor of biomaterials and bioengineering) – A Multiscale Biomechanics Approach to Extract Preventive Maintenance of the Dentoalveolar Fibrous Joint

10:35 a.m. – 11 a.m.       Break

11 a.m. – 12 p.m.       Manfred Auer (Lawrence Berkeley National Laboratory) – The Universe in a Cell

12 p.m. – 1 p.m.             Lunch

Afternoon (Attendees Choose Correlative Imaging 2 or Mentoring and Faculty Development)

Breakout #1
Correlative Imaging 2 – Grayson Marshall (distinguished professor emeritus), chair

1 p.m. – 1:40 p.m.          James Schuck (Lawrence Berkeley National Laboratory Molecular Foundry) – Optical Spectroscopic Imaging: Mapping Structure and Function at Length Scales That Matter

1:40 p.m. – 2:20 p.m.     Sam Webb (Stanford Synchrotron Radiation Lightsource) – Chemical Imaging of Natural Materials Using Synchrotron Radiation

2:20 p.m. – 3 p.m.          Paul Ashby (Lawrence Berkeley National Laboratory) – Imaging Chemical Composition at the Nanoscale

3 p.m. – 3:40 p.m.          Kirk Czymmek (Zeiss) – Advances in Correlative and Multiscale Microscopy for Biological Systems

3:40 p.m. – 4 p.m.          Discussion and Comments

4:10 p.m. – 4:30 p.m.     Final Discussion (all participants)

Breakout #2
Mentoring – Sally Marshall (UCSF, retired vice provost and distinguished professor emerita), chair

1 p.m. – 2 p.m.              Mitchell Feldman (UCSF, associate vice provost and director of faculty mentoring, professor of medicine) – Why You Need a Mentor and How to Find One

2 p.m. – 2:30 p.m.          David Drake (University of Iowa, professor of microbiology, AADR Board member) – Mentoring Experience - National Research Mentoring Network

2:30 p.m. – 3 p.m.          Thomas Lang (UCSF SOD, associate dean for research) – Funding Strategies in the Age of Scarcity

3 p.m. – 3:30 p.m.          Sally Marshall – Hints for Advancement as a Faculty Member

3:30 p.m. – 4 p.m.          Panel Discussion

4:10 p.m. – 4:30 p.m.     Final Discussion (all participants)