Chunlin Qin to Receive the 2016 IADR Distinguished Scientist Award in Pulp Biology & Regeneration

FOR IMMEDIATE RELEASE                                                                                            

IADR contact: Ingrid L. Thomas
+1.703.548.0066 or
ithomas@iadr.org

June 21, 2016

Alexandria, Va., USA - The International Association for Dental Research (IADR) will present Chunlin Qin with the 2016 IADR Distinguished Scientist Award in Pulp Biology & Regeneration. He will be recognized at the Opening Ceremonies of the 94th IADR General Session & Exhibition, Wednesday, June 22, 2016, in Seoul, Republic of Korea. This meeting will be held in conjunction with the 3rd Meeting of the IADR Asia Pacific Region and the 35th Annual Meeting of the IADR Korean Division.

Qin is a tenured professor in the Department of Biomedical Sciences at Baylor College of Dentistry, Texas A&M University Health Science Center, Dallas, USA. He earned his master’s degree and D.D.S at Harbin Medical University School of Dentistry, China; and his Ph.D. from Okayama University Graduate School of Dentistry, Japan. He completed his postdoctoral fellowship at the University of Texas Health Science Center at Houston Dental Branch, USA.

He has been a leader in the field of dentin matrix and pulp biology, and has an extraordinary international reputation. One example of his accomplishments is his important discoveries about the structure and functions of dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP), which are two molecules that play critical roles in odontoblast differentiation and dentin formation. He discovered that DMP1 is processed into NH2- and COOH-terminal fragments by proteolytic cleavage of specific peptide bonds. His team found that the NH2-fragments of DMP1 is primarily present as the proteoglycan form that has a single glycosaminoglycan (GAG) chain made of chondroitin-4-sulfate and linked to the core protein via Ser89 in mouse DMP1. His data also showed that the highly phosphorylated COOH-terminal fragment of DMP1 promotes biomineralization, whereas the proteoglycan form of DMP1 inhibits the formation and growth of hydroxyapatite crystals. Furthermore, his research work has established that the proteolytic cleavage of DMP1 at selected X-Asp bonds is an activation step essential to the formation of dentin and bone.

Qin’s studies on DSPP led to the discovery of the proteoglycan form for the NH2-terminal fragment of this protein and to the identification the GAG chain attachment sites in this proteoglycan. His team discovered that in addition to dentinogenesis, DSPP also plays a critical role for the development of cementum and alveolar bone. His group has proven that the proteolytic cleavage of DSPP at selected XAsp bonds activate this protein precursor. These fundamental discoveries on DMP1 and DSPP by Dr. Qin’s team have far-reaching impact in the field of pulp and dentin biology. More recently, Qin’s group revealed that FAM20C (a novel kinase) plays essential roles in the formation of mineralized tissues, and participate in the regulation of FGF23 and the maintenance of total body phosphorus homeostasis. His discoveries on FAM20C have not only made great impact on the research of dentin biology but also significantly influenced other biological fields.

The IADR Pulp Biology and Regeneration Award is supported by Dentsply Sirona and consists of a monetary prize and plaque. The award recognizes, encourages, and stimulates outstanding research contributions in the field of pulp biology and is one of the 17 IADR Distinguished Scientist Awards. This award is one of the highest honors bestowed by IADR.

About the International and American Associations for Dental Research
The International Association for Dental Research (IADR) is a nonprofit organization with nearly 10,500 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit www.iadr.org.

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