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Journal of Dental Research Centennial February 2019: Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health

Alexandria, VA, USA – 2019 marks the Centennial of the Journal of Dental Research (JDR). Over the last century the JDR has been dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry and to the oral cavity and associated structures in health and disease. To celebrate, the JDR is featuring a year-long commemorative article series and a podcast series that highlights topics that have transformed dental, oral and craniofacial research over the past 100 years.

In the February 2019 issue of the JDR, the article “Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health” provides an account of the developments related to saliva over the first 100 years of the JDR and outlines many of the biomarkers identified in saliva.

Authors Colin Dawes, University of Manitoba, Winnipeg, Canada, and David Wong, University of California, Los Angeles, USA, first cover findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology and the role of saliva in maintaining oral health and then highlight salivary diagnostics, salivaomics, saliva-exosomics in the context of the emerging theme of personalized and precision medicine.

“In the past decade, salivaomics studies have revealed the translation and clinical utilities of saliva for biomarker development,” said Wong. “Further investigation is still needed, but this emerging area of research has great potential.”

“Key future tasks will be validating salivary exosome biomarkers and determining the molecular mechanisms of exosome interaction between distal tumors and salivary glands,” said Dawes.

Throughout 2019, JDR Associate Editor, Nicholas Jakubovics, Newcastle University, England will include ‘Historical Highlights’ from the rich history of research findings published in the JDR.  In the February issue, Jakubovics highlights several issues including the concept that dental caries is caused by acid production from the metabolism of dietary carbohydrates by dental plaque microorganisms.

For many years, attempts to find correlations between salivary pH and dental caries were met with little success. However, in a series of papers between the late 1930’s and early 1940’s, Robert M. Stephan measured pH in dental plaque at the site of caries formation. Stephan demonstrated that intake of sugars resulted in a rapid drop in dental plaque pH followed by a slower rise to baseline — this characteristic response has become widely known as the ‘Stephan Curve’ [Stephan RM. (1944). Intra-oral hydrogen-ion concentrations associated with dental caries activity. J Dent Res 23(4):257-266].

“Stephan’s observations are fully aligned with current thinking in microbial ecology, that dental caries is associated with a shift to a more acidogenic dental plaque rather than a disease caused by a single pathogen,” said Jakubovics. “The seminal research done by Miller, Stephan and others highlighted in this article has laid the foundation for current research on how saliva impacts dental and oral health.”

The second JDR Centennial podcast, titled “Featured Podcast: Role of Saliva and Salivary Diagnostics in the Advancement of Oral Health” features a conversation between Dawes and Wong, moderated by Jakubovics.

Along with the article and podcast series, the legacy of the JDR will be honored during a celebration at the 97th General Session of the IADR, held in conjunction with the 48th Annual Meeting of the AADR and the 43rdAnnual Meeting of the Canadian Association for Dental Research, in Vancouver, British Columbia, Canada from June 19-22, 2019. For more information on the JDR Centennial, please visit: www.iadr.org/JDRcentennial.

About the Journal of Dental Research
The IADR/AADR Journal of Dental Research is a multidisciplinary journal dedicated to the dissemination of new knowledge in all sciences relevant to dentistry and the oral cavity and associated structures in health and disease.

The JDR ranks #2 in Impact Factor of 91 journals in the “Dentistry, Oral Surgery & Medicine” category at 5.380, ranks #2 of 91 in Article Influence with a score of 1.546 and continues to rank #1 of 91 journals in Eigenfactor with a score of 0.02095. The JDR’s 5-year Impact Factor has remained above 5 for the third year at 5.715 — ranking #2 of 91 journals. With over 19,000 citations, the JDR also boasts the most citations in the “Dentistry, Oral Surgery & Medicine” category.

About the International Association for Dental Research

The International Association for Dental Research (IADR) is a nonprofit organization with over 11,400 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit www.iadr.org. The American Association for Dental Research (AADR) is the largest Division of IADR with 3,300 members in the United States. To learn more, visit www.iadr.org/aadr.

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