Study Examines Whether Replacements for Missing Teeth Lower the Risk of Poor Cognition

Alexandria, VA – A study aiming to determine if the replacement of missing teeth with fixed prostheses may protect against cognitive decline was presented at the 52nd Annual Meeting & Exhibition of the AADOCR, in conjunction with the 47th Annual Meeting of the CADR. The AADOCR/CADR Annual Meeting & Exhibition took place at the Oregon Convention Center in Portland on March 15-18, 2023.

The study by Elizabeth Kaye of Boston University examined 577 men in the VA Normative Aging Study (NAS) and Dental Longitudinal Study. Tooth status and type of replacement, if any, were recorded at triennial dental exams (1969-2001). Masticatory efficiency was assessed with carrot chewing tests. The Spatial Copying Task (SCT) was administered up to four times between 1995 and 2001. The investigators defined poor cognition as any weighted SCT score <13 (lowest tertile of initial SCT scores in all NAS participants). Tooth-level Cox proportional regression, accounting for clustering within individuals, estimated the hazard of poor cognition, adjusted for education, epilepsy medication use, and time-varying values of tooth status (present, absent, fixed bridge/implant, removable replacement), age, cigarette smoking, and coronary heart disease.

The mean age at initial cognitive testing was 68±7 years. Forty-five percent of men had at least one low SCT score. Twenty-nine percent of participants lost no teeth during follow-up, 34% lost teeth that were not replaced, 13% had missing teeth subsequently replaced with fixed prostheses, and 25% had missing teeth replaced with removable prostheses. New fixed prostheses were associated with a lower hazard (HR=0.72, 95%CI=0.52-0.99) of poor cognition while new removable prostheses were associated with a higher hazard (HR=1.26, 95% CI=1.01-1.56). Loss of a tooth with no replacement was not associated with a significantly higher hazard (HR=1.05 95% CI=0.91-1.21) of poor cognition. Masticatory ability declined 6% in men with new fixed prostheses compared to 9%, 10%, and 13% in men with no tooth loss, new removable prostheses, and tooth loss but no replacement, respectively.

The study found that the replacement of missing teeth with fixed prostheses may protect against cognitive decline, and conservation of masticatory ability may play a role in the protective association.

This research was presented as part of the Interactive Talk presentation, “Fixed Prosthetic Replacements May Lower Cognitive Impairment Risk,” which took place on Thursday, March 16th, 2023, at 8:00 a.m. Pacific Daylight Time (UTC-07:00) during the “Oral and General Health” session from 8 a.m. – 9:30 a.m.

The American Association for Dental, Oral, and Craniofacial Research (AADOCR) is a nonprofit organization with a mission to drive dental, oral, and craniofacial research to advance health and well-being. AADOCR represents the individual scientists, clinician-scientists, dental professionals, and students based in academic, government, non-profit and private-sector institutions who share our mission. AADOCR is the largest division of the International Association for Dental Research. Learn more at www.aadocr.org.